Poster Presentation on Multiple Sclerosis

Title : Decreasing Grey Matter in Multiple Sclerosis; A serious disorder in the brain

 Presenter : Jes Paul

                    Albany Medical College, USA

Abstract : Multiple sclerosis (MS) is a chronic  degenerative disease of the central nervous system that is frequently accompanied by  decline in grey matter composition .

Specific patterns of brain atrophy in MS is associated with reduced gray matter . Even earlier studies also showed the abnormalities in gray matter networks several neurological and psychiatric disorders, such as Alzheimer disease and schizophrenia. The link between gray matter lessening and disability is more pronounced as the MS progresses .

The study,  aimed to investigate decreasing gray matter content in MS by hypothesing that the more pronounced network disorganization and disability there is more worse decrease in grey matter  in MS.A very random topology in MS patients was related to reduced grey matter, explaining variance beyond conventional MRI and volumetric measures. This suggests that during the progression of MS the gray matter networks will diminish contributing to  worsened disability,neuropathophysiological  and cognitive impairment. Advancements in to the grey matter morphology  showcases an improved relationship with clinical and cognitive observed profiles in MS.

In future research grey matter network-based pathology in MS which  lead to cognitive and physical disability, should be addressed  so that a serious neurological disorder like ms can be tackled to an extent.